Check with your doctor right away if you have dark urine, clay-colored stools, stomach pain, or yellow eyes or skin. If a dose is missed, it should be taken as soon as possible. If the dose was missed by more than 12 hours, advise patients not to take the missed dose and resume with the next scheduled dose.
Drug Interactions for Lipitor
- Before taking atorvastatin, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
- If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
- There is no specific drug interaction between alcohol and atorvastatin, but you may consider limiting your alcohol intake because statins plus excessive alcohol may raise your triglyceride levels and possibly lead to liver toxicity.
These may include bile acid resins and other cholesterol-lowering medications. The information contained in this document does not contain all possible side effects and other side effects or problems that may occur as a result of using this medicine. Check with your doctor for additional medical information about side effects or other health concerns. Call your doctor immediately if you experience any unusual or troublesome symptoms including significant weight loss or gain, dark urine, fever, or fatigue. Do not drink large amounts of grapefruit juice (1.2 liters or more) while taking atorvastatin. Large amounts of grapefruit juice can increase your risk of developing serious muscle problems.
Atorvastatin reduces total-C, LDL-C, apo B, and TG, and increases HDL-C in patients with hyperlipidemia (heterozygous familial and nonfamilial) and mixed dyslipidemia. Therapeutic response is seen within 2 weeks, and maximum response is usually achieved within 4 weeks and maintained during chronic therapy. Advise pregnant patients and patients who can become pregnant of the potential risk to a fetus. Advise patients to inform their healthcare provider of a known or suspected pregnancy to discuss if ATORVALIQ should be discontinued see Use In Specific Populations.
Researchers looked at the effect of two other statins, pravastatin and simvastatin, compared to a placebo (sugar pill) in 1016 people. Forty percent, or about 4 out of 10 women reported fatigue and loss of energy after exertion. Older people between 70 and 75 years of age also experienced this effect.
Does Atorvastatin interact with my other drugs?
Your doctor will check your liver enzymes with a simple blood test before you start treatment with statins. Atorvastatin is used to lower cholesterol levels in the blood and to reduce the risk of heart attack, stroke, and other cardiovascular complications in individuals with high cholesterol. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of atorvastatin in the elderly. However, elderly patients are more likely to have age-related kidney, liver, heart problems, or increased risk of muscle problems, which may require caution in patients receiving atorvastatin.
Approximately 70% of circulating inhibitory activity for HMG-CoA reductase is attributed to active metabolites. In animals, the ortho-hydroxy metabolite undergoes further glucuronidation. Renal impairment is a risk factor for myopathy and rhabdomyolysis.
Adverse Reactions From Clinical Studies Of LIPITOR In Pediatric Patients With HeFH
Leqvio is used in adults with high blood cholesterol levels (called primary hyperlipidemia) … This is not a complete list of side atorvastatin oral route description and brand names effects and others may occur. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of leflunomide in the elderly. However, elderly patients are more sensitive to the effects of leflunomide than younger adults. Ask your healthcare provider or pharmacist for a list of medicines if you are not sure.
Recommended Dosage In Adult Patients
The effect of 10 mg/day of atorvastatin on lipid levels was similar to that seen in previous clinical trials. While studies have not been conducted in patients with end-stage renal disease, hemodialysis is not expected to significantly enhance clearance of atorvastatin since the drug is extensively bound to plasma proteins. Plasma atorvastatin concentrations are lower (approximately 30% for Cmax and AUC) following evening drug administration compared with morning. Atorvastatin, as well as some of its metabolites, are pharmacologically active in humans. Individualization of drug dosage should be based on therapeutic response see DOSAGE AND ADMINISTRATION.
Atorvaliq
Atorvastatin plasma levels can be significantly increased with concomitant administration of inhibitors of CYP3A4 and transporters. Drug interactions can also lead to muscle pain or rhabdomyolysis. Use of higher doses of atorvastatin with certain medications can increase the risk of muscle pain. Always have your pharmacist run a drug interaction screen any time to start or stop a new medication. Of the predefined secondary endpoints, treatment with atorvastatin 80 mg/day significantly reduced the rate of coronary revascularization, angina, and hospitalization for heart failure, but not peripheral vascular disease.
What should I tell my healthcare provider before using atorvastatin?
Atorvastatin oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This may not be a complete list of medicines that can interact with atorvastatin.
LIPITOR reduces total-C, LDL-C, apo B, and TG, and increases HDL-C in patients with hyperlipidemia (heterozygous familial and nonfamilial) and mixed dyslipidemia. The proportions of subjects who experienced cardiovascular death, including the components of CHD death and fatal stroke, were numerically smaller in the LIPITOR 80 mg group than in the LIPITOR 10 mg treatment group. The proportions of subjects who experienced noncardiovascular death were numerically larger in the LIPITOR 80 mg group than in the LIPITOR 10 mg treatment group.
- They’ll do this typically 4 weeks after you start treatment with atorvastatin.
- It is important to promptly report any unexplained muscle pain or weakness to your healthcare provider.
- Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4and below.
- Evening dose administration is known to reduce the Cmax and AUC by 30% each.
If you agree that it is, you’ll likely take it long term once you reach your maintenance dose. For this use, your child’s doctor may use atorvastatin treatment alone. Or they may use it along with other therapies to lower LDL-C. Atorvastatin is used to lower LDL-C in children ages 10 years and older who also have HeFH or HoFH. Your doctor will likely start you on a low dosage and adjust it over time to reach the right amount for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.
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They’ll do this typically 4 weeks after you start treatment with atorvastatin. LIPITOR is extensively metabolized to ortho-and parahydroxylated derivatives and various beta-oxidation products. In vitro inhibition of HMG-CoA reductase by ortho-and parahydroxylated metabolites is equivalent to that of LIPITOR. Pup body weight was decreased through postnatal day 21 at 100 mg/kg/day, and through postnatal day 91 at 225 mg/kg/day.